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A 39-year-old man with idiopathic CD4+ lymphocytopenia was admitted to our hospital. He was diagnosed as having primary or secondary hypogammaglobulinemia because of the finding of low serum immunoglobulin level and rare T cells in his peripheral blood. Clinically, he developed gradually progressive lymphadenopathy and splenomegaly, accompanied by high serum levels of IgM and IgG and low IgA. His serum thymic hormone level was also high. Other immunologic tests and histologic studies of lymph nodes revealed no apparent findings. Based on the clinical and laboratory findings, he was diagnosed as having hyper-IgM syndrome (HIM), although the low CD4+ cells were non-immunodeficient. His laboratory findings showed the positive response to interferon-alpha therapy. It is possible that this patient is suffering from HIM associated with secondary hypogammaglobulinemia.The Microbiota-Gut-Brain Axis.
There is increasing evidence that the gut microbiota is able to influence central brain functions and behavior. To a large extent, these effects are mediated through the vagal nerve and its ascending and descending fibers, which connect different regions in the brain. Accordingly, the central effects of the gut microbiome are not limited to the gastrointestinal tract but can also be found in the brain stem and beyond, for instance in the amygdala, hippocampus, prefrontal cortex and hypothalamus. In the following review, we will give an overview of the different structures within the brain at which gut-microbiota-gut
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