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Share this: Like this: Blog Archive Visitors Disclaimers This blog is for entertainment purposes only. We do not own any of these videos and pictures. The content was found online and we are just posting them here to promote our website. We do not intend to violate copyright. If you are the rightful owner of any content that you believe has been used unfairly, please contact us via e-mail using this address arun-9440466[at]yahoo[dot]com. We will respond to your request shortly. Thank you.Cross-bridge properties and contractile function of rat heart from experimental diabetes. Heart from rats made diabetic by injection of streptozotocin was studied in an in vitro contractility system at a subnormal temperature (10 degrees C). Histological analysis indicated atrial and ventricular hypertrophy, fibrosis, and endocardial thickness consistent with mild heart failure. Neither cardiac weight (7.5 +/- 0.1 vs 7.1 +/- 0.1 g) nor fiber length (339 +/- 8 vs 305 +/- 9 microns) was altered. Sarcomere length of cross-bridges was prolonged (6.64 +/- 0.06 vs 6.22 +/- 0.06 microns) and observed as an increased rigor tension development relative to control. Maximum tension developed at half-maximal activation in the presence of 10 microns [Ca2+] was equivalent to that of controls (90 +/- 9 vs 75 +/- 9 micron/s) despite a decreased Ca(2+)-sensitivity (pCa/pT changed by -0.10 +/- 0.02 pCa/pT). Maximum tension increased with fiber length due to mechanical coupling, and tension/pCa was unaffected by fiber length. Actin polymerization was unaffected. Maximal velocity (Vmax) of tension development in the presence of phalloidin was diminished in diabetic (0.094 +/- 0.013 vs 0.124 +/- 0.015 micron/s). These data suggest that atria and left ventricle from diabetic rats develop myocardial hypertrophy, fibrosis, and heart failure in a manner comparable to that observed in humans with long-standing, uncontrolled diabetes mellitus.Prevalence of nosocomial infections among ICU patients in Southwestern Nigeria. Nosocomial infections have been regarded as one of the most important health problems which have impeded 37a470d65a
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